ApoE-status

How to determine your ApoE genotype from 23andMe raw data

If you are reading this article, you probably already know the reason for understanding your ApoE status. If you have any copies of the ApoE4 gene, then you are at increased risk of inflammation, heart disease, strokes, and Alzheimer’s.

This gene has gotten all the attention in the Alzheimer’s department, but I want you to know that this gene has much larger ramifications.

You can deactivate this gene by eating a diet low in refined sugars / carbohydrates, high in vegetables, and full of great fats.

If you have an ApoE4, you need to make sure that you are tracking your inflammation because you may need to get more aggressive based on your disease activity.

ApoE4 determines are you disease RISK; whereas, inflammation testing determines your actual disease ACTIVITY.

Disease Risk = Do I have the ability to have the disease?
Disease Activity = Do I have presence of the disease?

What do my genes mean?

You get 2 copies of the ApoE gene.
Disease Risk: If you get one copy of ApoE4, then you are at increased risk.
For example: ApoE 3/4 or ApoE 2/4

Disease Risk: If you get two copies of ApoE4, then you are at an extremely high risk. Luckily, this is very rare.
For example: ApoE 4/4

Low risk: If you do not get any ApoE4, then you are at lower risk, but it does not mean that you cannot develop Alzheimer’s.
For example: ApoE 3/3, ApoE 2/2, or ApoE 2/3

Instructions how to determine your ApoE Status:

1) Login to 23andMe
2) Click the dropdown menu in the top right by your name.
3) Click “Browse Raw Data”
4) Type rs429358 and search
5) Write down what’s written under “Your Genotype”
6) Type rs7412 and search
7) Write down what’s written under “Your Genotype”
8) Look at the graphic below to determine your ApoE status.